HEMLIBRA Supplies & Storage

What you need to take HEMLIBRA

  • HEMLIBRA is available in vials and doesn’t need to be mixed
  • Vials should be kept refrigerated but can be outside of the refrigerator for up to 7 days
  • Your healthcare provider will determine your HEMLIBRA dose based on your weight. If your weight changes, tell your healthcare provider

HEMLIBRA comes in the following 4 dosing vials. Talk to your doctor to see which dosing option is right for you.

Sky Blue

30 mg/mL


60 mg/0.4 mL


105 mg/0.7 mL


150 mg/mL

To inject HEMLIBRA, you will use a transfer needle with filter, a syringe, and an injection needle. You can learn more about how to prepare and inject HEMLIBRA in the HEMLIBRA Instructions for Use pamphlet that comes with your HEMLIBRA.

Transfer needle with filter


25- to 27-gauge injection needle

Supplies may look different from the ones above, depending on your pharmacy.

How should I store HEMLIBRA?

  • Store your HEMLIBRA in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze it and do not shake it
  • Keep your HEMLIBRA in its original package to protect it from light until you are ready to use it
  • If needed, unopened vials of HEMLIBRA can be stored out of the refrigerator and then returned to the refrigerator
  • HEMLIBRA should not be stored out of the refrigerator for more than a total of 7 days or at a temperature greater than 86°F (30°C)
  • Once you transfer HEMLIBRA to a syringe, you must use it right away

How should I properly dispose of sharps?

  • Throw away any unused HEMLIBRA left in the vial, and your used needles and syringes in a sharps disposal container immediately after use 
  • Do not throw away these materials in your household trash or toilet
  • Do not reuse any needles or syringes
  • Do not overfill your sharps container. It is important to safely dispose of your sharps when the container reaches ¾ full

Keep HEMLIBRA and all medicines out of the reach of children.

Get an FDA-approved sharps container from Genentech, or learn how and where to dispose of your used HEMLIBRA needles by calling 1-866-HEMLIBRA (1-866-436-5427) for information about the Genentech sharps disposal program.

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Important Safety Information & Indication


HEMLIBRA is a prescription medicine used for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and children, ages newborn and older, with hemophilia A with or without factor VIII inhibitors.

What is the most important information I should know about HEMLIBRA?

HEMLIBRA increases the potential for your blood to clot. People who use activated prothrombin complex concentrate (aPCC; Feiba®) to treat breakthrough bleeds while taking HEMLIBRA may be at risk of serious side effects related to blood clots.

These serious side effects include: 

  • Thrombotic microangiopathy (TMA), a condition involving blood clots and injury to small blood  vessels that may cause harm to your kidneys, brain, and other organs 
  • Blood clots (thrombotic events), which may form in blood vessels in your arm, leg, lung, or head  

Talk to your doctor about the signs and symptoms of these serious side effects, which can include: 

  • Confusion
  • Stomach, chest, or back pain
  • Weakness
  • Nausea or vomiting
  • Swelling, pain, or redness
  • Feeling sick or faint
  • Decreased urination
  • Swelling of arms and legs
  • Yellowing of skin and eyes
  • Eye pain, swelling, or trouble seeing
  • Fast heart rate
  • Numbness in your face
  • Headache
  • Shortness of breath
  • Coughing up blood

If you experience any of these symptoms during or after treatment with HEMLIBRA, get medical help right away. 

Carefully follow your healthcare provider’s instructions regarding when to use an on-demand bypassing agent or factor VIII, and the dose and schedule to use for breakthrough bleed treatment. If aPCC (Feiba®) is needed, talk to your healthcare provider in case you feel you need more than 100 U/kg of aPCC (Feiba®) total. 

Your body may make antibodies against HEMLIBRA, which may stop HEMLIBRA from working properly. Contact your healthcare provider immediately if you notice that HEMLIBRA has stopped working for you (eg, increase in bleeds).

The most common side effects of HEMLIBRA include: injection site reactions (redness, tenderness, warmth, or itching at the site of injection), headache, and joint pain. These are not all of the possible side effects of HEMLIBRA. You can speak with your healthcare provider for more information.

What else should I know about HEMLIBRA?

See the detailed “Instructions for Use” that comes with your HEMLIBRA for information on how to prepare and inject a dose of HEMLIBRA, and how to properly throw away (dispose of) used needles and syringes.

  • Stop taking your prophylactic bypassing therapy the day before you start HEMLIBRA
  • You may continue taking your prophylactic factor VIII for the first week of HEMLIBRA

HEMLIBRA may interfere with laboratory tests that measure how well your blood is clotting and create an inaccurate result. Speak with your healthcare provider about how this may affect your care. 

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Only use HEMLIBRA for the condition it was prescribed. Do not give HEMLIBRA to other people, even if they have the same symptoms that you have. It may harm them.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, or herbal supplements. Keep a list of them to show your healthcare provider and pharmacist.

Before using HEMLIBRA, tell your healthcare provider about all of your medical conditions, including if you are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.

Since HEMLIBRA was tested in males, there is no information on whether HEMLIBRA may impact your unborn baby or breast milk. Females who are able to become pregnant should use birth control during treatment.

Side effects may be reported to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.

Please see Important Safety Information, including Serious Side Effects, as well as the HEMLIBRA full Prescribing Information and Medication Guide.