Injecting HEMLIBRA


How to prepare and inject your shot of HEMLIBRA

Watch the step-by-step injection video below to help improve the injection experience.

Haga clic aquí para ver este video en español.

Tips for a more comfortable HEMLIBRA injection

HEMLIBRA® (emicizumab-kxwh) Injecting HEMLIBRA Thermometer

Allow HEMLIBRA to full reach room temperature before injecting

  • Take HEMLIBRA out of the refrigerator and allow it to reach room temperature before use. Giving HEMLIBRA enough time to warm up may help make the injection more comfortable
  • HEMLIBRA should not be stored out of the refrigerator for more than a total of 7 days or at a temperature greater than 86°F (30°C)

Pick an injection area that feels best for you

  • Injections can be given in the front and middle of the thigh, the stomach (excluding 2 inches around the navel), or the outer area of the upper arm (only if a caregiver is giving the injection)
  • Once you find an area that works, you can continue injecting there—just make sure you rotate sites by at least 1 inch each time you inject
HEMLIBRA® (emicizumab-kxwh) Injecting HEMLIBRA Injection Angle

Inject slowly, at a proper angle

  • Ensuring you’re injecting at the proper angle for you may help ease the process. Injections must be given anywhere between a 45° and a 90° angle. Work with your doctor to find your preferred injection angle
  • Insert the needle quickly and firmly. Once inserted, slowly press down on the plunger while injecting. Pushing slowly may help improve the experience

Ready, Steady, Lenny

The only phone-based game designed to help entertain and empower your child during their hemophilia A injection

Ready, Steady, Lenny uses your phone to turn injection time into adventure time! The world of Lenny the Llama is filled with interactive elements that will help engage and calm your child during their injection.

Kids can choose from 1 of 3 captivating adventures to participate in, and earn a custom bandage as a reward for helping Lenny out!

More tips for caregivers

HEMLIBRA® (emicizumab-kxwh) Injecting HEMLIBRA Family Icon

Make your child a part of the injection process

  • Do this in a safe, age-appropriate way, like having them choose from the injection sites or set up the injection mat
  • This can help your child feel empowered and focused on having a job
HEMLIBRA® (emicizumab-kxwh) Injecting HEMLIBRA Reward Icon

Keep your child engaged with a fun distraction

  • A fun distraction, like their favorite game or TV show, may help reduce your child's stress and keep them at ease during the injection
HEMLIBRA® (emicizumab-kxwh) Injecting HEMLIBRA Vial Icon

Remember that HEMLIBRA provides flexible dosing options*

  • Children are always growing and changing, so talk to your doctor about changing your child's dosage and dosing schedule so it continues to meet their needs as they get older
  • Having a dosing regimen that works for your child can help improve the treatment experience

*After 4 weekly loading doses, HEMLIBRA can be taken once a week, once every 2 weeks, or once every 4 weeks.

For more information on injecting HEMLIBRA, read the Instructions for Use or download the additional resources below.

Whether you feel confident in your approach to injections or are just learning for the first time, you can always reach out to your Account and Community Manager (ACM) for 1:1 support. ACMs are Genentech employees and do not provide medical advice. Always talk to your doctor about treatment options.

INJECTION RESOURCES

HEMLIBRA® (emicizumab-kxwh) Injecting HEMLIBRA Inject Icon Taking HEMLIBRA
Learning to Inject Brochure

See step-by-step instructions for administering HEMLIBRA

HEMLIBRA® (emicizumab-kxwh) Injecting HEMLIBRA Guide Icon
Tips and Tricks

Your guide to a more comfortable injection experience

HEMLIBRA® (emicizumab-kxwh) Injecting HEMLIBRA Calendar Icon 2
Injection Log

Keep track of your HEMLIBRA doses

Sign Up for One-on-One Support

Your local ACM is here to help answer your HEMLIBRA questions.

Important Safety Information & Indication

What is HEMLIBRA?

HEMLIBRA is a prescription medicine used for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and children, ages newborn and older, with hemophilia A with or without factor VIII inhibitors.

What is the most important information I should know about HEMLIBRA?

HEMLIBRA increases the potential for your blood to clot. People who use activated prothrombin complex concentrate (aPCC; Feiba®) to treat breakthrough bleeds while taking HEMLIBRA may be at risk of serious side effects related to blood clots.

These serious side effects include: 

  • Thrombotic microangiopathy (TMA), a condition involving blood clots and injury to small blood  vessels that may cause harm to your kidneys, brain, and other organs 
  • Blood clots (thrombotic events), which may form in blood vessels in your arm, leg, lung, or head  

Talk to your doctor about the signs and symptoms of these serious side effects, which can include: 

  • Confusion
  • Stomach, chest, or back pain
  • Weakness
  • Nausea or vomiting
  • Swelling, pain, or redness
  • Feeling sick or faint
  • Decreased urination
  • Swelling of arms and legs
  • Yellowing of skin and eyes
  • Eye pain, swelling, or trouble seeing
  • Fast heart rate
  • Numbness in your face
  • Headache
  • Shortness of breath
  • Coughing up blood

If you experience any of these symptoms during or after treatment with HEMLIBRA, get medical help right away. 

Carefully follow your healthcare provider’s instructions regarding when to use an on-demand bypassing agent or factor VIII, and the dose and schedule to use for breakthrough bleed treatment. If aPCC (Feiba®) is needed, talk to your healthcare provider in case you feel you need more than 100 U/kg of aPCC (Feiba®) total. 

Your body may make antibodies against HEMLIBRA, which may stop HEMLIBRA from working properly. Contact your healthcare provider immediately if you notice that HEMLIBRA has stopped working for you (eg, increase in bleeds).

The most common side effects of HEMLIBRA include: injection site reactions (redness, tenderness, warmth, or itching at the site of injection), headache, and joint pain. These are not all of the possible side effects of HEMLIBRA. You can speak with your healthcare provider for more information.

What else should I know about HEMLIBRA?

See the detailed “Instructions for Use” that comes with your HEMLIBRA for information on how to prepare and inject a dose of HEMLIBRA, and how to properly throw away (dispose of) used needles and syringes.

  • Stop taking your prophylactic bypassing therapy the day before you start HEMLIBRA
  • You may continue taking your prophylactic factor VIII for the first week of HEMLIBRA

HEMLIBRA may interfere with laboratory tests that measure how well your blood is clotting and create an inaccurate result. Speak with your healthcare provider about how this may affect your care. 

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Only use HEMLIBRA for the condition it was prescribed. Do not give HEMLIBRA to other people, even if they have the same symptoms that you have. It may harm them.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, or herbal supplements. Keep a list of them to show your healthcare provider and pharmacist.

Before using HEMLIBRA, tell your healthcare provider about all of your medical conditions, including if you are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.

Since HEMLIBRA was tested in males, there is no information on whether HEMLIBRA may impact your unborn baby or breast milk. Females who are able to become pregnant should use birth control during treatment.

Side effects may be reported to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.

Please see Important Safety Information, including Serious Side Effects, as well as the HEMLIBRA full Prescribing Information and Medication Guide.