How blood coagulates to help stop a bleed

Meet factor VIII, a protein that is involved in one of the steps of the blood coagulating process.
Factor VIII becomes factor VIIIa when an injury happens.

Factor VIIIa brings two other proteins (factor IXa and factor X) together, allowing the blood coagulation process to continue, stopping a bleed.

In people with hemophilia A who have low or missing factor VIII, the blood coagulation process cannot continue normally.

Coagulation is a natural process that helps the body stop a bleed.

VIII, IX, and X are the Roman numerals for 8, 9, and 10, respectively. Did you know that Roman numerals were used throughout Europe until the 14th century?

How HEMLIBRA helps blood coagulate

HEMLIBRA acts like a bridge, bringing factor IXa and factor X together to allow the blood coagulation process to continue without needing to replace factor VIII.

HEMLIBRA is different from factor VIII.

Because HEMLIBRA is different from factor VIII, it works even in the presence of factor VIII inhibitors.

How HEMLIBRA and FVIIIa get along in the laboratory setting

Laboratory studies show that when both factor VIIIa and HEMLIBRA are available, factor VIIIa binds to factors IXa and X more readily and tightly than HEMLIBRA.

Therefore, based on laboratory studies, overcoagulation was not observed when HEMLIBRA and factor VIII were present.

Watch HEMLIBRA Stories

See patients talk about their experiences with HEMLIBRA


Find out about HEMLIBRA studies for people with and without inhibitors