HEMLIBRA® is the first and only once-weekly subcutaneous treatment for patients with inhibitors
Once trained by a healthcare provider, a patient may self-inject, or use the help of a caregiver.
- Advise the patient to follow the recommendations in the Instructions for Use, including proper sharps disposal
The HEMLIBRA Instructions for Use contains more detailed instructions on the preparation and administration of HEMLIBRA.
Important information for administering a HEMLIBRA injection
Visually inspect HEMLIBRA for particulate matter and discoloration before administration. HEMLIBRA for subcutaneous administration is a colorless to slightly yellow solution. Do not use if particulate matter is visible or product is discolored.
A syringe, a transfer needle, and an injection needle are needed to withdraw HEMLIBRA solution from the vial and inject it subcutaneously.
Refer to the HEMLIBRA Instructions for Use for handling instructions when combining vials. Do not use different HEMLIBRA vial concentrations when combining vials to administer prescribed dose.
- Administer doses of HEMLIBRA up to 1 mL with a 1 mL syringe. A 1 mL syringe fulfilling the following criteria may be used: Transparent polypropylene or polycarbonate syringe with Luer‑Lok™ tip, graduation 0.01 mL, sterile, for injection only, single-use, latex-free and non-pyrogenic, commercially available in the US.
- Administer doses of HEMLIBRA greater than 1 mL and up to 2 mL with a 2 mL or 3 mL syringe. A 2 mL or 3 mL syringe fulfilling the following criteria may be used: Transparent polypropylene or polycarbonate syringe with Luer‑Lok™ tip, graduation 0.1 mL, sterile, for injection only, single‑use, latex‑free, and non‑pyrogenic, commercially available in the US.
- A transfer needle fulfilling the following criteria may be used: Stainless steel needle with Luer-Lok™ connection, sterile, 18 gauge, length 1½ inch, semi-blunted tip, single-use, latex-free, and non-pyrogenic, commercially available in the US.
- An injection needle fulfilling the following criteria may be used: Stainless steel with Luer-Lok™ connection, sterile, 26 gauge, maximal length ½ inch, single-use, latex-free, and non-pyrogenic, including needle safety feature, commercially available in the US.
Administer each injection at a different anatomic location (upper outer arms, thighs, or any quadrant of abdomen) than the previous injection. An injection should never be given into moles, scars, or areas where the skin is tender, bruised, red, hard, or not intact.
Administration of HEMLIBRA in the upper outer arm should only be performed by a caregiver or healthcare provider.
Discard any unused HEMLIBRA remaining in the single-dose vial.
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- Refrigeration: store between 2ºC to 8ºC (36ºF to 46ºF) in the original carton to protect from light; the product is stable at room temperature for up to 7 cumulative days; do not freeze or shake